476 Skin microbiome alterations in infants before clinical atopic dermatitis

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Microbiome in atopic dermatitis

Atopic dermatitis (AD) is a common chronic inflammatory skin disease affecting ~10-20% of the general population. AD is characterized by disturbances in epidermal barrier function and hyperactive immune response. Recently, changes in the skin and intestinal microbiome have been analyzed in more detail. The available data suggest a link between disturbed skin microbiome and course of the disease...

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Atopic dermatitis (AD) is a common inflammatory skin disorder and characterized by abnormalities in both skin barrier structures and alternations of the immune response. Molecular genetics have dramatically changed our vision of the micro-organisms colonizing the human skin and recently well-documented changes in the skin microbiome in atopic dermatitis have become evident. The microbiome shift...

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The role of the skin microbiome in atopic dermatitis.

Atopic dermatitis (AD) is a common skin disease that affects a large proportion of the population worldwide. The incidence of AD has increased over the last several decades along with AD's burden on the physical and psychological health of the patient and family. However, current advances in understanding the mechanisms behind the pathophysiology of AD are leading to a hopeful outlook for the f...

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The skin microbiome in allergen-induced canine atopic dermatitis.

BACKGROUND Studies focusing on next-generation sequencing of the bacterial 16S rRNA gene have allowed detailed surveys of skin bacterial populations (microbiota) of the skin. HYPOTHESIS/OBJECTIVES This study evaluated temporal changes in the skin microbiota in a canine model of atopic dermatitis. ANIMALS Eight atopic dogs previously sensitized with house dust mites (HDM). METHODS The dogs...

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ژورنال

عنوان ژورنال: Journal of Investigative Dermatology

سال: 2016

ISSN: 0022-202X

DOI: 10.1016/j.jid.2016.02.512